PINC AI Healthcare Database (PINC AI)

Solicitation description

The National Institute of Health (NIH) intends to negotiate and award a purchase order without providing for full and open competition to Commonwealth Informatics Inc. The purpose of this requirement is to provide a firm-fixed-price contract for the PINC AI Healthcare Database (PINC AI) at the NIH Division of Intramural Research. The primary objectives of the NIH Clinical Center, Critical Care Medicine Department (CCMD) for this project include general, specific, and ad hoc tasks requested of Commonwealth Informatics Inc. These tasks will be performed under a labor-hour contract until all allotted hours have been utilized. The requested tasks encompass, but are not limited to, the following: Generation of project-specific datasets using the PINC AI database for studies including, but not limited to: Epidemiologic investigations in sepsis, antibiotic resistance, and invasive fungal infections Comparative effectiveness of therapies for critically ill patients where clinical trials are not feasible Commonwealth Informatics will perform various ad hoc analyses and prepare deliverables as requested for the “pruned” PINC AI data, in accordance with the Statement of Work (SOW) found in the Proposal Appendix or provided as a separate attachment. Commonwealth will provide PINC AI data loading tasks as outlined below: Generate project-specific data files based on investigator feedback and share during meetings/webinars (frequency to be determined, as needed) Troubleshoot in real-time with NIH investigators on study queries and data inconsistencies Construct algorithms to generate specific populations from the data that are of interest to NIH investigators Correspond on various projects via email In addition, Commonwealth Informatics will provide project-specific and/or ad hoc tasks as requested via this Labor Hour contract until the allotted hours have been exhausted. General tasks may include, but are not limited to, the following areas: Mapping and curating near-real-time versions of datasets Generation of eSOFA scores Mapping September 2023 - September 2025 data to add more recent data to current and ongoing projects Generation of analysis-ready data files for each of the projects Commonwealth Informatics Inc. (CII; Waltham, MA) is the only known informatics company with over five years of experience working with the Cerner Healthfacts database, a large multi-hospital electronic health record-based dataset with detailed information on patient physiologic, laboratory, pharmacy, and administrative data. The CCMD at NIH/CC has previously collaborated with Harvard’s Department of Population Medicine on a study utilizing Cerner Healthfacts as the data source and CII for data management and analysis. This study provided an estimate of the prevalence of sepsis in the US and was published in JAMA in 2017. CCMD has also collaborated with NIAID DIR, which has contracted with CII in the past on projects involving the Cerner Healthfacts database. These...

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