Federal solicitation · DARPA-PS-26-129 · back to recent
Protein ENGineering (PENG)
- Agency
- DEPT OF DEFENSE
- Status
- Open
- Response deadline
- October 19, 2026
- Posted
- August 21, 2026
- Set-aside
- Not listed
- NAICS
- 541714
- Source
- View on SAM.gov
- Last checked
- 2026-10-01
Solicitation description
The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals for the development of a multifunctional, target-agnostic platform for precise, programmable editing of endogenous proteins. The goal of the Protein ENGineering (PENG) program is to transition proteome engineering from a collection of isolated, bespoke tools into a universal, software-defined discipline. The PENG program will establish a comprehensive, integrated platform composed of modular targeting, generalizable effector chemistries, and multiplexed control systems. Rather than developing isolated, target-specific tools, performers will integrate novel splicing, ligation, and co-translational techniques to directly recognize, modify, and rewrite endogenous proteins within complex biological architectures. Performers may explore multiple technical paths, progressively advancing their approaches from foundational validation to robust demonstrations of efficacy. Ultimately, this integrated platform will be validated in high-fidelity cellular models (e.g., organoids), to provide an integrated proof-of-concept at the tissue level.
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Data this profile does not cover
- No likely incumbent surfaced; the solicitation number did not match any award record in the trailing window.
- No award records for NAICS 541714 in the trailing 12 months, so the vendor field is unavailable.