RNA sequencing

Solicitation description

SOURCES SOUGHT NOTICE This is a Sources Sought Notice only. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding the availability and capability of qualified small businesses, including Service-Disabled Veteran-Owned Small Businesses (SDVOSBs) and Veteran-Owned Small Businesses (VOSBs), to perform the work described below. Responses to this notice will be used by the Government to make appropriate acquisition decisions. Title: Strand-Specific RNA Sequencing (RNA-Seq) Services for Gene Expression Profiling of Human Choroid Plexus Tissue Acquisition ID#: 36C24126Q0705 NAICS Code: 541714 Research and Development in Biotechnology (except Nanobiotechnology) Product Service Code (PSC): Q301 Medical - Reference Laboratory Testing Contracting Office: VA Bedford Healthcare System, Bedford, Massachusetts Anticipated Period of Performance: 1 year from date of award 1. Purpose The Department of Veterans Affairs (VA) is conducting market research to identify qualified sources capable of providing strand-specific RNA sequencing services in support of a neurodegenerative disease research program. This notice is issued in accordance with FAR Part 10 to determine whether qualified Service-Disabled Veteran-Owned Small Businesses (SDVOSBs), Veteran-Owned Small Businesses (VOSBs), or other small businesses exist that can perform this requirement, in order to make an appropriate small business set-aside or full-and-open competition determination. The determination of whether this acquisition will be set aside for SDVOSBs/VOSBs, set aside for other small businesses, or conducted as a full-and-open competition will be made based on the responses received to this notice. Responding firms are strongly encouraged to clearly identify their socioeconomic status and certifications, as this information will directly inform that determination. No solicitation exists at this time. This notice does not obligate the Government to issue a solicitation or award a contract. 2. Background The Bedford, Massachusetts VAMC requires strand-specific RNA sequencing services to support gene expression profiling of post-mortem human choroid plexus tissue as part of a research program investigating Chronic Traumatic Encephalopathy (CTE), Alzheimer's Disease (AD), and TDP-43 proteinopathy. Data generated under this effort will be integrated with separately acquired DNA methylation and proteomic data from the same sample set. 3. Summary of Requirement The contractor shall provide: Sample handling and quality control (QC) assessment of submitted total RNA samples Library preparation with rRNA depletion and QC assessment Illumina paired-end sequencing at approximately 60 million read pairs per sample (2x150bp configuration), strand-specific (directional) protocol Raw data alignment and quality reporting Physical delivery of raw sequencing data (FASTQ files) via hard drive Quantity: 269 de-identified human...

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