BioStabilization Systems (BoSS)

Solicitation description

Amendment 4: The purpose of this amendment is to amend the BoSS ISO. An updated version of the ISO, with changes in red font, is included as an attachment to this amendment. These changes are applicable to IV&V proposers only. Changes to the ISO include: extending the Solution Pitch deadline for IV&V proposers to May 21, 2026. Attachment 3A Cost Proposal Narrative removes references to TA1/TA2. Attachment 4A Cost Proposal Spreadsheet removes references to TA1/TA2. Please be sure to use the new Attachments listed above in your submission, which can be found in the Attachments section of this poting. This Amendment DOES NOT extend the deadline for IV&V Solution Summaries. ------------------------------------------------------------------------------------------------------------ Amendment 3: The purpose of this amendment is to amend the Attachments. Changes to the attachments are listed below: Attachment 3 Cost Proposal Narrative: references to "lead organization" were changes to "lead member." See red text on the cover page. Attachment 4 Cost Proposal Spreadsheet: On the General tab in the yellow box, under the "Instructions for using this template." See red text on the General tab. Please carefully review the amended ISO for all changes. ------------------------------------------------------------------------------------------------------------ Amendment 2: The purpose of this amendment is to amend the BoSS ISO. An updated version of the ISO, with changes in red font, is included as an attachment to this amendment. Changes to the ISO include (but are not limited to): clarification of examples of out-of-scope approaches (Table 1) update to capability requirements (Section 1.3 Program Overview) update to allowable IV&V partner entity types (Section 2) update to reporting requirements (Section 3.4 Programmatic Deliverables) Please carefully review the amended ISO for all changes. ------------------------------------------------------------------------------------------------------------ Amendment 1 corrects a formatting error on references to Table 2. ------------------------------------------------------------------------------------------------------------ Program Description: The BioStabilization Systems (BoSS) program aims to transform how live cell-based therapies are stabilized, manufactured, and distributed. At its core, BoSS addresses a foundational bottleneck in the delivery of advanced cell and gene therapies (CGTs): the critical dependence on ultra-cold conditions (-80 to -196?C) for storage and transport. BoSS will yield a bioprocessing system that enables scalable production of thermally stable cells, paving the way for a new era of efficient and resilient manufacturing and distribution of biologics without any need for cold storage. BoSS-developed technologies will also accelerate many other avenues in biotechnology that directly impact healthcare, including bio-surveillance, regenerative medicine, large-scale genetic testing,...

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