Participant Basic Agreement (PBA) Opportunity - Threat Agnostic Host-Directed Therapeutics

Solicitation description

This is a continuous, open announcement with no deadline unless specifically noted. 1. Strategic Opportunity: The Capability Program Executive for Chemical, Biological, Radiological, and Nuclear Defense (CPE CBRND) invites interested parties to participate in the HEALER portfolio, a next-generation host directed medical countermeasure initiative. HEALER seeks to develop a diverse portfolio of threat agnostic, host-directed therapeutics that enhance the body’s ability to withstand, mitigate, and recover from the complex physiological impacts of CBRN threats. Because the underlying pathophysiology of injury following CBRN exposure and civilian critical care challenges are often governed by convergent host response mechanisms, this program creates a viable commercial opportunity that exceeds the traditional CBRN mission space. This initiative represents a significant opportunity for industry collaborators by focusing on dual-use therapeutics. This alignment of national security priorities with commercial market incentives offers a path to sustainable product development. 2. Program Vision: Building Threat-Agnostic Host Resilience The goal of the HEALER portfolio is to create a new generation of therapeutics enabling the 'Host' to recover from physiological impacts and maintain operational effectiveness even under duress. The program focuses on delivering medical countermeasures that provide layered physiological protection to the Warfighter by targeting one or more of the following critical host systems: Neurological Protection Respiratory Stabilization Immune Modulation Hematologic & Vascular Function Cellular Stress & Repair Pathways This integrated approach will ensure the development of a diverse and robust portfolio of threat-agnostic capabilities, empowering the host through enhanced resilience. 3. Call for Collaborators: Who Should Apply? This announcement serves as an invitation to the full spectrum of drug development organizations. A. Therapeutic Development Collaborators: We invite submissions from developers of host-directed therapeutic candidates. B. Drug Development Support Collaborators: We also invite participation from organizations specializing in contract research, development, and manufacturing (CROs/CDMOs) and other firms with expertise in preclinical testing (e.g., efficacy, pharmacology, toxicology), clinical trial execution, cGMP manufacturing, regulatory submissions, and advanced modeling. Collaboration with expert service providers is essential to accelerate development within the HEALER portfolio. 4. Submission Requirements & Process The HEALER portfolio will be executed under the terms of a Participant Basic Agreement (PBA). Interested entities shall submit a white paper (not to exceed five pages, not including a cover page) that addresses the areas outlined below. In addition, companies shall state entity’s willingness to team or collaborate with other entities that may also have a PBA for the HEALER portfolio. A....

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Data this profile does NOT cover

• No likely incumbent surfaced; the solicitation number did not prefix-match any award in the FPDSAward window.
• No FPDSAward rows for NAICS 541714 in the trailing 12 months; vendor concentration unavailable.